CENTELLA®

wound healing – collagen booster – antioxidant

INCI
Butylene Glycol, Centella Asiatica Leaf Extract

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ONE PAGER

Centella asiatica, a perennial herb with traditional nutritional and therapeutic value, exhibits a wide range of therapeutic activities, including antioxidant, anti-inflammatory, antimicrobial, anticarcinogenic, and neuroprotective effects. It’s recommended for treating skin conditions like lupus, eczema, and psoriasis. The extract stimulates collagen synthesis and maturation, reduces inflammatory markers (IL-1-beta, IL-6, TNF-alpha), and has significant antioxidant activity. Key constituents are terpenoids (asiaticoside, centelloside, madecassoside) and triterpenic acids (asiatic, centellic, madecassic, terminolic).

We have developed a hydro-soluble, colorless extract of Centella asiatica, overcoming the challenge of low bioavailability. This extract supports skin health by enhancing antioxidant defenses, reducing inflammation, and boosting collagen production, thus aiding in wound healing and well ageing.

EFFICACY TESTS

ANTIOXIDANT ACTIVITY

Formation of oxidative stress plays a crucial role in skin aging processes.

1% Centella asiatica extract (TS) significantly improves antioxidant activity of UVA-irradiated keratinocytes for all times of UV exposure. (NC, negative control; PC, positive control).

Bar chart showing the reduction of reactive oxygen species (ROS) in cells treated with Centella Asiatica Leaf Extract under UV exposure at various time intervals compared to negative and positive controls.

COLLAGEN PRODUCTION FOR HEALTHY SKIN

We tested the ability of Centella asiatica extract in stimulating collagen production and reducing pro-inflammatory cytokines.

Both are involved in wound healing: collagen by attracting fibroblasts and encouraging new collagen production activating the clotting cascade, while uncontrolled inflammation delays healing and increases scarring.

1% Centella asiatica extract significantly increased collagen production by fibroblast and reduced IL-6 levels in keratinocytes thus positively impact on skin recovery.

 
Bar chart illustrating the effect of Centella Asiatica Leaf Extract on IL-6 production at various concentrations compared to negative and positive controls.
Bar chart showing the effect of Centella Asiatica Leaf Extract on collagen production at various concentrations compared to negative and positive controls.

Key Product Details

% OF USE

1.0 – 5.0%

APPLICATIONS

This ingredient is ideal for use in anti-wrinkle and anti-aging creams, enhancing the efficacy of skincare formulations.

TECHNICAL DATA
APPEARANCE CLEAR LIQUID
COLOUR COLORLESS
ODOUR SOFT, CHARACTERISTIC
ACTIVE SUBSTANCE ≥ 25%
PH AT 25°C (5% IN WATER) 5.5 – 7.5
SPECIFIC GRAVITY (25°C) 0.9 ÷ 1.1 g/ml
BIODEGRADABILITY BIODEGRADABLE
PROPERTIES
  • Versatile therapeutic properties: Exhibits antioxidant, anti-inflammatory, antimicrobial, anticarcinogenic, and neuroprotective effects.
  • Skin health support: Enhances antioxidant defenses, reduces inflammation, and boosts collagen production, aiding in wound healing and well-aging.
  • Improved antioxidant activity: Significantly improves antioxidant activity of UVA-irradiated keratinocytes.
  • Enhanced collagen production: Stimulates collagen production by fibroblasts, positively impacting skin recovery.

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