IN&OUT DETOX®

Moisturizing, purifying plant-derived anti-pollution complex

INCI
Polyglycerin-6, Propanediol, Solanum Melongena (Eggplant) Fruit Extract, Bioflavonoids, Brassica Oleracea Italica (Broccoli) Extract

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ONE PAGER

In & out DETOX® is a natural active plant complex designed to protect the skin effectively against external and internal stressors. It helps in fighting damages due to pollutants, UV radiations, free radicals and chemicals by getting rid of oxidative stress intermediates.

COMPOSITION

Broccoli (Sulforaphane): Activates Phase 2 detox enzymes, protecting skin against UV radiation, environmental pollutants, and internal reactive molecules (Boddupalli S. et al., 2012).

Bioflavonoids (Nobiletin): Found in citrus peel, exhibits antioxidant, anti-inflammatory, anti-allergic, antitumor, and antiangiogenic properties (Kim E. et al., 2022).

Ethiopian Eggplant (Flavonoids, Polyphenols, Phytosterols): Offers strong antioxidant activity, reduces inflammation and tissue damage, and enhances collagen production and tissue metabolism (Han M. et al., 2021).

EFFICACY TESTS

ANTIOXIDANT ACTIVITY

Superoxide dismutase (SOD) is a key enzyme in cells, acting as a powerful antioxidant and part of the defense against harmful reactive oxygen species (ROS), as described by Ighodaro O.M. and Akinloye O.A. in 2018.

In & out DETOX® has been shown to significantly increase SOD2 expression in cells at various concentrations, particularly after 6 and 24 hours of application, and also enhances Catalase expression, highlighting its effectiveness in boosting the body’s natural antioxidant defenses.

Bar charts showing the effect of In & Out Detox® at different concentrations on SOD2 and Catalase activity at 6 hours and 24 hours, compared to untreated and positive control groups.
 

Clinical evaluation of soothing and lenitive efficacy

 

Corneometric measurement shows that in & out DETOX® significantly increased skin hydration and its effect is long lasting. In addition, in & out DETOX® significantly improves Trans Epidermal Water Loss (p<0.027 and p<0.028 respectively) and Erythema index in subjects with SDS-induced skin irritation.

Bar charts showing the effect of In & Out Detox® 2% on hydration, Transepidermal Water Loss (TEWL), and erythema measurements at different time points (T0, T1H, T2H, T4H, 7D).

Clinical evaluation of purifying efficacy

 

2% in & out DETOX® in a detergent, significantly reduces sebometry and skin desquamation thus improving hydrolipidic film and protecting skin barrier. in & out DETOX® shows also pore cleanliness. 

Bar charts showing the effect of In & Out Detox® 2% on sebum levels and desquamation index at different time points (T0, T1H, T4H).
Images showing close-ups of skin texture before and after treatment, highlighting improvements in smoothness and clarity.

Key Product Details

% OF USE

2 – 5%

APPLICATIONS

Haircare: shampoos, balsams, masks, serums.
Skincare: conditioning body creams
Personal care: detergents, shower gels, shaving foams, beard balms

TECHNICAL DATA
APPEARANCE CLEAR LIQUID
COLOUR VERY LIGHT YELLOW
ODOUR SOFT, CHARACTERISTIC
DRY RESIDUE (105°C) 77 – 83%
SPECIFIC GRAVITY (25°C) 1.1 ÷ 1.3 G/ML
PH (5% WATER SOLUTION AT 25°C) 4 – 6
PROPERTIES
  • 100% Plant-Derived and Palm-Free: Soluble in water, ethanol, and propylene glycol.
  • Enhances Hair Quality: Provides shiny, glossy, and soft hair while reducing static charges. Offers excellent lubricity, snag-free wet combability, and dry compatibility.
  • Improves Formulation and Provides Antimicrobial Protection: Enhances foam quality, slightly increases overall viscosity, and has antimicrobial effects against gram-positive and gram-negative bacteria, yeasts, and moulds.

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