CRYOCARE®
Biomimetic natural ingredient for skin protection from cold and dehydration
INCI
Glycerin, Aqua, Hippophae rhamnoides fruit extract
Cold Protection
Skin Hydration
Repair & Regeneration
CRYOCARE® is a biomimetic, plant-derived ingredient derived from Hippophae rhamnoides (Sea Buckthorn), a Himalayan plant that thrives in extreme cold thanks to its natural antifreeze strategies.
Through an innovative, sustainable extraction process—combining ultrasounds and tangential flow filtration—CRYOCARE® is enriched with bioactive compounds while eliminating impurities such as fibers and debris.
At the core of its efficacy is the chitinase protein, which adapts to cold stress by reinforcing the skin barrier and reducing moisture loss. Rich in flavonoids, omega-6 fatty acids (including gamma-linolenic acid), and vitamins C & E, it enhances hydration, repair, and skin renewal.
Beyond cold protection, CRYOCARE® shields the skin from photo-thermal stress by mitigating the harmful effects of infrared (IR) radiation. It reduces oxidative stress markers by up to 60%, preventing deep cellular damage and premature aging.
Ideal for cold, dry environments and urban settings, CRYOCARE® strengthens the skin’s natural defenses. Backed by research, it is biodegradable, non-irritating, and environmentally safe, aligning with sustainable and eco-conscious formulations.
COLD IMPACT ON SKIN
- Causes dryness, irritation, and increased sensitivity, especially in cold, dry environments.
- Leads to moisture loss, skin barrier weakening, and discomfort due to thickening of the outer layer.
- Prolonged exposure can result in roughness, redness, and conditions like eczema or chilblains.
Hippophae rhamnoides STRATEGIES
- Adapts to extreme cold by combineing structural and biochemical strategies to thrive in freezing conditions, protecting itself from damage.
- Produces chitinase, a hydrolytic enzyme that becomes, under cold acclimation, an anti-freeze protein to protect against freezing.
- Contains high levels of flavonoids and carotenoids, providing antioxidant protection and promoting skin regeneration.
CRYOCARE®: A BIOMIMETIC SOLUTION
- Containing chitinase, mimics the behaviour of Hippophae rhamnoides to reinforce the skin barrier against cold and dryness.
- Rich in flavonoids and omega-6 fatty acids, supports hydration, repair, and regeneration.
- Neutralizes free radicals to reduce the impact of environmental stress.
- Reduces stress markers in keratinocytes subjected to photo-thermal stress.
EFFICACY TESTS
cryocare® IN-VITRO EFFICACY ON KERATINOCYTES SURVIVAL
Cell viability has been assessed on Keratinocyte cell line exposed to hypothermic shock (two repeated exposures of 1 hour at -20°C) with or without CRYOCARE®.
0.15% CRYOCARE® significantly (p<0.05) increased the survival of keratinocytes exposed to thermal shock up to the quadruple.
C-: cells not treated or exposed to thermal shock
C+: cells exposed to thermal shock
C-: cells not treated or exposed to thermal shock
C+: cells exposed to thermal shock
cryocare® in-vivo protective anti-freeze effect
Volunteers’ forearm has been treated with a base emulsion, with or without CRYOCARE®, and exposed to controlled cold and dry temperature and humidity conditions using the W&HS – weather & humidity simulator, a patented instrument.
Skin hydration has been evaluated after 1 hour: 5% CRYOCARE® determined a significant increase (***p<0,001) in skin hydration by 44,6% compared to the control area with an improvement greater (+50%) than the placebo product (*p<0,05).
This indicates the in-vivo thermal protective efficacy of CRYOCARE®.
cryocare® PROTECTION AGAINST IR-INDUCED SKIN STRESS
CRYOCARE®, in human keratinocytes subjected to photo-thermal stress (environmental temperature above 42°C and a total exposure of 300 J/m2 energy) significantly (p<0.05) reduces the stress marker HSP72 levels in a dose-dependent manner demonstrating a protective efficacy towards damage agents as IR radiation.
In addition to lowering HSP72 levels, CRYOCARE® enhances skin resilience, supporting adaptation to environmental stress while preserving vitality and a youthful appearance.
Key Product Details
% OF USE
2% – 5%
APPLICATIONS
Ideal for emulsions or transparent water-based formulations
TECHNICAL DATA
| APPEARANCE | CLEAR LIQUID |
| COLOUR | LIGHT AMBER |
| ODOUR | CHARACTERISTIC |
| DRY RESIDUE (105°C) | > 90 % |
| SPECIFIC GRAVITY (25°C) | 1.2 – 1.3 g/ml |
| PH (5% WATER SOLUTION AT 25°C) | 4 – 6 |
PROPERTIES
- Cold resistance: Reinforces the skin barrier against harsh weather conditions.
- Hydration boost: Provides immediate and long-lasting hydration, even in low humidity.
- Antioxidant power: Neutralizes free radicals to minimize environmental stress.
- Skin repair: Promotes regeneration with omega-6, vitamins C and E, and essential fatty acids.
- Natural and sustainable: Derived from Hippophae rhamnoides, and biodegradable, ensuring safety for skin and the environment.
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