CRYOCARE®
Biomimetic natural ingredient for skin protection from cold and dehydration
Biomimetic natural ingredient for skin protection from cold and dehydration
INCI
Glycerin, Aqua, Hippophae rhamnoides fruit extract
CRYOCARE® is a biomimetic ingredient derived from Hippophae rhamnoides (Sea Buckthorn), a Himalayan plant renowned for thriving in freezing conditions thanks to its natural antifreeze strategies.
The extract is enriched in active ingredients through a sustainable and innovative extraction process involving ultrasounds and tangential flow filtration, which remove waste substances such as fibers and debris.
Key to its efficacy is the protein chitinase, which adapts under cold stress to function as an antifreeze, helping to reinforce the skin barrier. CRYOCARE® is also rich in flavonoids, omega-6 fatty acids (including gamma-linolenic acid), and vitamins C and E, all of which contribute to hydration, repair, and skin renewal.
Thanks to these properties, CRYOCARE® provides effective defense in cold, dry environments, reducing the impact of environmental stress. According to the literature, the active ingredient is expected to be biodegradable, non-irritating, and environmentally safe, aligning with its natural origin and supporting its sustainability profile.
COLD IMPACT ON SKIN
Hippophae rhamnoides STRATEGIES
CRYOCARE®: A BIOMIMETIC SOLUTION
Cell viability has been assessed on Keratinocyte cell line exposed to hypothermic shock (two repeated exposures of 1 hour at -20°C) with or without CRYOCARE®.
0.15% CRYOCARE® significantly (p<0.05) increased the survival of keratinocytes exposed to thermal shock up to the quadruple.
C-: cells not treated or exposed to thermal shock
C+: cells exposed to thermal shock
C-: cells not treated or exposed to thermal shock
C+: cells exposed to thermal shock
Volunteers’ forearm has been treated with a base emulsion, with or without CRYOCARE®, and exposed to controlled cold and dry temperature and humidity conditions using the W&HS – weather & humidity simulator, a patented instrument.
Skin hydration has been evaluated after 1 hour: 5% CRYOCARE® determined a significant increase (***p<0,001) in skin hydration by 44,6% compared to the control area with an improvement greater (+50%) than the placebo product (*p<0,05).
This indicates the in-vivo thermal protective efficacy of CRYOCARE®.
2% – 5%
Ideal for emulsions or transparent water-based formulations
APPEARANCE | CLEAR LIQUID |
COLOUR | LIGHT AMBER |
ODOUR | CHARACTERISTIC |
DRY RESIDUE (105°C) | > 90 % |
SPECIFIC GRAVITY (25°C) | 1.2 – 1.3 g/ml |
PH (5% WATER SOLUTION AT 25°C) | 4 – 6 |