CRYOCARE®

Biomimetic natural ingredient for skin protection from cold and dehydration

INCI
Glycerin, Aqua, Hippophae rhamnoides fruit extract

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CRYOCARE® is a biomimetic ingredient derived from Hippophae rhamnoides (Sea Buckthorn), a Himalayan plant renowned for thriving in freezing conditions thanks to its natural antifreeze strategies.

The extract is enriched in active ingredients through a sustainable and innovative extraction process involving ultrasounds and tangential flow filtration, which remove waste substances such as fibers and debris.

Key to its efficacy is the protein chitinase, which adapts under cold stress to function as an antifreeze, helping to reinforce the skin barrier. CRYOCARE® is also rich in flavonoids, omega-6 fatty acids (including gamma-linolenic acid), and vitamins C and E, all of which contribute to hydration, repair, and skin renewal.

Thanks to these properties, CRYOCARE® provides effective defense in cold, dry environments, reducing the impact of environmental stress. According to the literature, the active ingredient is expected to be biodegradable, non-irritating, and environmentally safe, aligning with its natural origin and supporting its sustainability profile.

COLD IMPACT ON SKIN

  • Causes dryness, irritation, and increased sensitivity, especially in cold, dry environments.
  • Leads to moisture loss, skin barrier weakening, and discomfort due to thickening of the outer layer.
  • Prolonged exposure can result in roughness, redness, and conditions like eczema or chilblains.

Hippophae rhamnoides STRATEGIES

  • Adapts to extreme cold by combineing structural and biochemical strategies to thrive in freezing conditions, protecting itself from damage.
  • Produces chitinase, a hydrolytic enzyme that becomes, under cold acclimation, an anti-freeze protein to protect against freezing.
  • Contains high levels of flavonoids and carotenoids, providing antioxidant protection and promoting skin regeneration.

CRYOCARE®: A BIOMIMETIC SOLUTION

  • Containing chitinase, mimics the behaviour of Hippophae rhamnoides to reinforce the skin barrier against cold and dryness.
  • Rich in flavonoids and omega-6 fatty acids, supports hydration, repair, and regeneration.
  • Neutralizes free radicals to reduce the impact of environmental stress.

EFFICACY TESTS

cryocare® IN-VITRO EFFICACY ON KERATINOCYTES SURVIVAL

Cell viability has been assessed on Keratinocyte cell line exposed to hypothermic shock (two repeated exposures of 1 hour at -20°C) with or without CRYOCARE®.

0.15% CRYOCARE® significantly (p<0.05) increased the survival of keratinocytes exposed to thermal shock up to the quadruple.

 

C-: cells not treated or exposed to thermal shock
C+: cells exposed to thermal shock

C-: cells not treated or exposed to thermal shock
C+: cells exposed to thermal shock

cryocare® in-vivo protective anti-freeze effect

Volunteers’ forearm has been treated with a base emulsion, with or without CRYOCARE®, and exposed to controlled cold and dry temperature and humidity conditions using the W&HS – weather & humidity simulator, a patented instrument.

Skin hydration has been evaluated after 1 hour: 5% CRYOCARE® determined a significant increase (***p<0,001) in skin hydration by 44,6% compared to the control area with an improvement greater (+50%) than the placebo product (*p<0,05). 

This indicates the in-vivo thermal protective efficacy of CRYOCARE®.

 

Key Product Details

% OF USE

2% – 5%

APPLICATIONS

Ideal for emulsions or transparent water-based formulations

TECHNICAL DATA
APPEARANCE CLEAR LIQUID
COLOUR LIGHT AMBER
ODOUR CHARACTERISTIC
DRY RESIDUE (105°C) > 90 %
SPECIFIC GRAVITY (25°C) 1.2 – 1.3 g/ml
PH (5% WATER SOLUTION AT 25°C) 4 – 6
PROPERTIES
  • Cold resistance: Reinforces the skin barrier against harsh weather conditions.
  • Hydration boost: Provides immediate and long-lasting hydration, even in low humidity.
  • Antioxidant power: Neutralizes free radicals to minimize environmental stress.
  • Skin repair: Promotes regeneration with omega-6, vitamins C and E, and essential fatty acids.
  • Natural and sustainable: Derived from Hippophae rhamnoides, and biodegradable, ensuring safety for skin and the environment.
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