EPSAN® PLUS is a new preservative system made of natural ingredients that has an antimicrobical effect against yeast, fungi, gram-positive and negative bacteria, making it suitable for versatile applications in the nutraceutical and cosmetic industry.

COMPONENTS

Polylysine

Polylysine is a natural homo-polymer created from L-lysine. It typically has a polymerization degree ranging between 25 and 35 and possesses a molecular weight around 5000. This compound is produced through bacterial fermentation. A notable function of Polylysine in cosmetic applications is its ability to inhibit the bonding of NF-kB with DNA.

p-Anisic Acid

p-Anisic acid, which is alternatively known as 4-methoxybenzoic acid or draconic acid, represents one of the isomers of anisic acid. It is a natural constituent found in anise. This compound is recognized for its antiseptic or germicidal properties, making it a valuable ingredient in cosmetic formulations.

HOW IT WORKS

EPSAN® PLUS attaches to the cell membrane of the microbe, it damages the membrane structure causing the material, energy and information transmission of the cell to stop. This will eventually leads to the intracellular lysosomal membrane rupture, induce the micro-organisms to autolysis and the breakage of the Intracellular lysosomal membrane causes the death of the bacterial cell.

INCOMPATIBILITIES

The Polylysine binds to polysaccharides (murein or bacterial mucopeptide) present in the cell walls of bacteria and denatures them.

Since polysaccharides of bacterial origin are present also in compounds obtained through fermentation (e.g. Xanthan gum) the same phenomenon of denaturation occurs also in this case.

It is therefore advisable to not use substances obtained through a fermentation process in formulas containing EPSAN® PLUS as preservative system.

A good replacement to Xantan gum as thickener are Tara gum (Caesalpinia Spinosa Gum) and Guar gum.